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Used as an infusion, decoction and extract. King's American Dispensatory, 1898: 'This drug possesses the tonic properties of gentian and similar bitters. It is valued in Hindustan, where it is much employed in urinary complaints with uneasiness in the region of the kidneys, frequent urging to urinate, which is accomplished with difficulty, and in cases of uric acid deposits. It is a remedy also for convalescence from exhausting sickness, and for atonic and nervous forms of dyspepsia. Dose of chirata, 10 to 20 grains; fluid extract, 10 to 20 minims; infusion (ss to boiling water Oj), fli to flii, 3 times a day.' According to Ayurveda, this herb is a bitter tonic, stomachic. It is useful in liver and kidney disorders. From the National Library of Medicine: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=journals: Phytother Res. 1999 Feb;13(1):24-30. Antihepatotoxic activity of Swertia chirata on carbon tetrachloride induced hepatotoxicity in rats. Karan M, Vasisht K, Handa SS. University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India. The methanol extract of Swertia chirata was evaluated for antihepatotoxic activity against carbon tetrachloride induced liver toxicity in experimental rats. The extract was found to be active and on fractionation into butanol soluble and chloroform soluble fractions, the activity was traced and found more profound in the chloroform soluble fraction. The butanol soluble bitter rich fraction showed marginal activity. The results based on biochemical estimations have been expressed statistically and are additionally supported by histopathological examination of the liver of experimental rats and pentobarbitone induced sleep time studies in mice. Indian J Exp Biol. 1997 Apr;35(4):384-8. Hepatoprotective effect of Swertia chirata on rat. Mukherjee S, Sur A, Maiti BR. Department of Zoology, University of Calcutta, India. Present work was undertaken to ascertain the hepatoprotective effect of Swertia chirata in albino rats. Intraperitoneal injection of CCl4 (1 ml/kgbody wt on every 72 hr. for 16 days) significantly increased serum aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT), and alkaline phosphatase (ALP) activities and bilirubin level in rat, but liver glycogen and serum cholesterol levels were decreased. Histologically it produced hepatocytic necrosis especially in the centrilobular region. Simultaneous treatments with S. Chirata (in different doses, viz, 20, 50 and 100 mg/kg body wt daily) and CCl4 (similar dose to that mentioned earlier) caused improvement at both biochemical and histopathological parameters compared to that of CCl4 treatment alone but it was most effective when S. chirata was administered in a moderate dose (50 mg/kg body wt). Drugs Exp Clin Res. 1993;19(2):69-73. Protective effect of Swertia chirata against indomethacin and other ulcerogenic agent-induced gastric ulcers. Rafatullah S, Tariq M, Mossa JS, al-Yahya MA, al-Said M
Manufacturer: Bazaar of India SKU: 39313 Category: Capsules, Extracts, I-Z-Kidney/Urinary Tract
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